Internet Search Assignment There is a tremendous amount of important genetic information available online, in fact, some information is really available only online. I would like you to explore some of what is available online so the assignment is to find out all that you can about any gene in humans that has been cloned and that you are interested in. This includes the genes function, the phenotypes of different common mutanty alleles and whether they are dominant or recessive, the genes location, and the genes amino acid sequence. The report is worth 20 points and should include the url of the database record and a url for the amino acid sequence. You can email your result to your discussion leader or turn it in during your discussion section on the week of December 6th. Start your search at the Online Mendelian Inheritance in Man (OMIM) site. Too be sure the gene has been cloned look for the "DNA" button near the top of the OMIM report, if you don't see the DNA button look for another gene. If you really aren't interested in any humans genes and wat to find something from another organism I have links to other databases below, most of these are much harder to use than OMIM so I would strongly encourage you to stick to the human genes. There is a grading rubric for this assignment that you might find useful. Online Mendelian Inheritance in Man (OMIM) This is a searchable database with information about most known human genes and genetic diseases. It includes phenotypes, inheritance (dominant, recessive, etc.), chromosomal location, different alleles, information about the gene (if it has been cloned), and a bibliography. Search OMIM -- Online Mendelian Inheritance in Man NCBI version of OMIM (use this one if the one above is busy) Mouse gene database (also OMIM) This includes mouse genes along with OMIM and can also be used to search for information about human genes. Online Mendelian Inheritance in Animals (OMIA) This is a searchable database with information about most known animal genes and genetic diseases. It includes phenotypes, inheritance (dominant, recessive, etc.), chromosomal location, different alleles, information about the gene (if it has been cloned), and a bibliography. FlyBase This is a searchable database with information about most known Drosophila genes. It includes phenotypes, inheritance (dominant, recessive, etc.), chromosomal location, different alleles, information about the gene (if it has been cloned), and a bibliography. TIGR Database (TDB) This is a collection of molecular biology databases containing DNA and protein sequence, gene expression, cellular role, isology class, taxonomic and sample collection data for a variety of species. TDB currently comprises the Microbial Database (MDB, containing the genome sequences of Haemophilus influenzae, Methanococcus jannaschii, and Mycoplasma genitalium), the Human cDNA Database (HCD), the Expressed Gene Anatomy Database (EGAD), Sequences, Sources, Taxa (SST), and the Arabidopsis thaliana Database. Genetics (VL) Virtual Library page on genetics. Has links to all of the different organism databases (look here for dog, cat, tree, etc. databases).   Other sites of interest CSUBIOWEB - GENETICS/MOLECULAR BIOLOGY This site has links to many different genetic sites with descriptions of the sites. Agricultural Genome Information Server (AGIS) Links to many agricultural sites (wheat genome, cow genome, etc.) Primer on Molecular Genetics (Department of Energy) A good tutorial on subjects like Southern blots, RFLP mapping, DNA sequencing, etc. Genome Analysis: A Laboratory Manual A tutorial on what do do after you've cloned a gene (how to search the database, analyse your sequence, etc.) The Human Genome Project: Where will it take us? Propaganda for the Human Genome Project The GDB Browser A database of all of the results from the Human Genome Project including genetic maps of the human chromosomes, genes, probes, etc. GenLink: A human genetics resource More human chromosome maps with locations of all mapped genes. Gene Therapy Weekly A news weekly with information about the various attempts to cure genetic diseases with gene therapy. Transgenic Mouse Database A database with information about all of the different genetically altered mouse strains. BLAST Database Searches at NCBI If you have a DNA or protein sequence you can search the entire genbank database for any similar sequences. Pedro's BioMolecular Research Tools - Part 1 A collection of links to all of the sites that will help you analyse a DNA or protein sequence. Do you want to search for intron exon boundaries in a genomic sequence? Check for a transmembrane domain in your gene? Compare your gene to other genes? etc. This is a very large site and may take a little while to load. MendelWeb Want to read Mendel's paper? In German or an annotated English translation. A good place to brush up on your Mendelian genetics. KUMC Genetics Education Center Kansas University site with links to many educational genetic sites. Science's Next Wave Career information for young scientist - want to know what's happening in the science job market? Produced by Science magazine. News in Bioscience and Medicine News about molecular genetics, in particular what's happening online (new web sites, newsgroups, new services, etc.) Reviews of hot topics in Biology (CSA) Abstracts and reviews of "hot" areas in biology from Cambridge Scientific Abstracts Index to Glossary of Genetic Terms A large glossary of genetic terms (this one can take a while to download) Jeffrey R. Bell's Bookmarks Yet more genetic sites on the web Bell Schierenbeck Parker Pushnik CSU Chico Library This document is copyright of Jeff Bell Last Update: Saturday, November 27th, 1999