Recombination
- three types of recombination (strand exchange)
- homologous - requires extensive sequence homology
(chromosomal recombination)
- Holliday model
- homologous pairing
- nicks on two different strands exchange and ligation between different strands
- branch migration
- nick opposite strands and ligate
- gene conversion - a non-reciprocal exchange
- a consequence of branch migration and excision repair
- Holliday model
- site-specific - always occurs at the same location
(viruses)
- lambda phage integration
- illegitimate - not site specific (transposons)
- homologous - requires extensive sequence homology
(chromosomal recombination)
Bell CSU Chico Library
This document is copyright of Jeff Bell
Last Update: Wednesday, August 12, 1998